Window of Opportunity Trial of Apristor for PR+ Breast cancer
Initiation of this study targeted for summer 2019.
Apristor (onapristone extended release) is a potent and specific antagonist of the progesterone receptor that is orally administered. Currently, there are no approved therapies that selectively target PR+ cancers. Preliminary preclinical and clinical data suggest that Apristor has anticancer activity by inhibiting the binding of progesterone receptor to chromatin, downregulating cancer stem cell mobilization, and blocking immune evasion.
Apristor has not been approved for marketing by any regulatory authority.
Early breast cancer.
Clinical Trial Description:
A prospective, window of opportunity, single-arm, multicenter study assessing the effect of Apristor on breast cancer biology in women with early breast cancer.