our focus

 
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Our Commitment to Patients
With Progesterone Receptor Positive (PR+) Cancers

At Context Therapeutics, we are passionate about improving health and committed to helping people with cancer. Our initial clinical focus is on developing our investigational oral progesterone receptor antagonist, Apristor, in PR+ rare ovarian cancer, endometrial cancer, and breast cancer.

 
PR+ Rare Ovarian Cancers

PR+ Rare Ovarian Cancers

 
PR+ Endometrial Cancer

PR+ Endometrial Cancer

 
PR+, ER+, HER2- Breast Cancer

PR+, ER+, HER2- Breast Cancer

 
 

Rare Ovarian Cancers

Ovarian cancer is comprised of several subtypes based on biophysical and molecular determinants. Subtypes that respond to progesterone signaling are typically rare and are often associated with worse prognosis. These subtypes include Low Grade Serous Ovarian Cancer (LGSOC) and Granulosa Cell Tumor of the Ovary.

Breast Cancer

There are approximately 750,000 metastatic breast cancer patients worldwide. Of those patients, 50-70% have breast cancer that is driven by aberrant hormone signaling via activation of progesterone receptor (PR) and/or estrogen receptor (ER) signaling.